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COVID‐19 and hepatic involvement: The liver as a main actor of the pandemic novel
Author(s) -
Napodano Cecilia,
Pocino Krizia,
Stefanile Annunziata,
Marino Mariapaola,
Miele Luca,
Gulli Francesca,
Basile Valerio,
Pandolfi Franco,
Gasbarrini Antonio,
Rapaccini Gian Ludovico,
Basile Umberto
Publication year - 2021
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12977
Subject(s) - liver injury , pandemic , covid-19 , natural history , medicine , liver disease , liver damage , immunology , disease , virology , pathology , infectious disease (medical specialty)
In the natural history of SARS‐CoV‐2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre‐existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID‐19 are still unclear but the liver damage in SARS‐CoV‐2 infection seems to be directly caused by virus‐induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS‐CoV‐2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID‐19 in patients with pre‐existing liver diseases.