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The pathogenesis of cutaneous lupus erythematosus: The aberrant distribution and function of different cell types in skin lesions
Author(s) -
Zhou Xinyu,
Yan Jinli,
Lu Qianjin,
Zhou Honghao,
Fan Lan
Publication year - 2021
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12933
Subject(s) - interferon , immunology , cell type , pathogenesis , disease , immune system , biology , interferon type i , systemic lupus erythematosus , plasmacytoid dendritic cell , lupus erythematosus , cell , medicine , dendritic cell , pathology , antibody , genetics
Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon‐κ(IFN‐κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Recently, keratinocytes selectively produced IFN‐κ is identified to be a key to trigger type I interferon responses in CLE. Other immune cells such as plasmacytoid dendritic cells (pDCs) are identified to be relevant origin of type I interferons (type I IFNs) which are central to the development of CLE lesions and responsible for mediating Th1 cell activity. Other types of cells such as neutrophils, B cells and Th17 cells also are involved in the development of this disease. The close interaction of those cells composes a comprehensive and complicated network in CLE. In this review, we discussed the aberrant distribution and function of different cells types involved in this disease and will offer a new direction for research and therapy in the near future.