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The roles of SOCS 3 and STAT 3 in bacterial infection and inflammatory diseases
Author(s) -
Gao Yu,
Zhao Honglei,
Wang Peng,
Wang Jun,
Zou Lili
Publication year - 2018
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12727
Subject(s) - socs3 , suppressor of cytokine signalling , cytokine , janus kinase , stat protein , stat3 , suppressor of cytokine signaling 1 , jak stat signaling pathway , pim1 , biology , microbiology and biotechnology , signal transduction , socs2 , stat , cancer research , immunology , phosphorylation , tyrosine kinase , cancer , genetics , serine , suppressor
The suppressor of cytokine signalling‐3 ( SOCS 3) is well known as a feedback inhibitor of the Janus kinases‐signal transducer and activator of transcription 3 ( JAK / STAT 3) signalling pathway, which mediates the signal transduction of many cytokines, growth factors and hormones during many cellular processes. The critical role of SOCS 3 is manifested by its binding to both the JAK kinase and the cytokine receptor, which can result in the inhibition of STAT 3 phosphorylation. STAT 3 triggers variety of genes expression in response to cytokine ( IL ‐6 family, IL ‐10) and growth factor stimulation and thus plays a critical role in many cellular biological processes involved in anti/pro‐inflammatory responses, cell growth and cell death. SOCS 3 might act directly either by hampering JAK activation or by mediating the ubiquitination and subsequent proteasome degradation of the cytokine/growth factor/hormone receptor. Generally, SOCS 3 is a negative regulator for cytokine or hormone signalling. But in some cases, SOCS 3 regulates the inflammatory responses positively through inhibiting STAT 3. An increasing number of reports showed abnormal expression levels of SOCS 3/ STAT 3 in different myeloid and lymphoid cells as well as in various non‐hematopoietic cells, which suggested its involvement in various infection and inflammatory diseases. In this review, we described the role of SOCS 3 and STAT 3 expression in different cell populations in regulating the outcomes of infection and inflammatory diseases.