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Decreased Expression of IFNG ‐ AS 1 , IFNG and IL ‐1B Inflammatory Genes in Medicated Schizophrenia and Bipolar Patients
Author(s) -
Ghafelehbashi H.,
Pahlevan Kakhki M.,
Kular L.,
Moghbelinejad S.,
Ghafelehbashi S. H.
Publication year - 2017
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12620
Subject(s) - inflammation , pathogenesis , immunology , messenger rna , rna , long non coding rna , gene expression , medicine , gene , biology , genetics
Although aberrant expression of cytokines such as IL ‐1B and IFNG in blood from psychiatric patients supports a role of inflammation in the pathogenesis of the disease, little is known about mechanisms underlying their regulation. We aimed to evaluate the putative role of IFNG ‐ AS 1 long non‐coding RNA (lnc RNA ) in controlling of IFNG locus in patients with schizophrenia ( SZ ) and bipolar ( BP ). We analysed the expression levels of IFNG ‐ AS 1 long non‐coding RNA , and IFNG and IL ‐1B mRNA s in blood cells from 27 SZ ‐ and 30 BP ‐medicated patients and in 32 healthy controls. Our data showed that IFNG ‐ AS 1 expression dramatically decreased in BP and SZ patients compared with controls and was significantly correlated with IFNG expression in patients specifically. Transcript levels of IL ‐1B were also significantly reduced in BP and SZ patients compared with controls. No significant differences in the expression of IFNG ‐ AS 1, IFNG and IL ‐1B genes were found between patients with BP and SZ . Our data shed further light on the potential role of inflammation, and more particularly inflammatory lnc RNA s, in SZ and BP diseases and their pharmacological treatment.