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The Dual Role of Treg in Cancer
Author(s) -
Frydrychowicz M.,
Boruczkowski M.,
KoleckaBednarczyk A.,
Dworacki G.
Publication year - 2017
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12615
Subject(s) - foxp3 , immune system , transcription factor , biology , immune tolerance , cancer research , immunology , treg cell , cancer , antigen , tumor microenvironment , t cell , gene , il 2 receptor , genetics
Regulatory T cells (Tregs) represent a small subpopulation of CD 4 + cells. Tregs are characterized by the expression of transcription factor Forkhead box protein 3 (FoxP3), also known as scurfin. Tregs are modulators of adaptive immune responses and play an important role in maintaining tolerance to self‐antigens, providing the suppression associated with tumour microenvironment as well. These immunomodulatory properties are the main reason for the development of numerous therapeutic strategies, designed to inhibit the activity of cancer cells. However, due to Treg subpopulation diversity and its many functional pathways, the role of these cells in the cancer development and progression is still not fully understood.