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Epigenetics: The Future Direction in Systemic Sclerosis
Author(s) -
Walczyk M.,
ParadowskaGorycka A.,
Olesinska M.
Publication year - 2017
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12595
Subject(s) - epigenetics , biology , genetic association , epigenesis , single nucleotide polymorphism , genetics , disease , genome wide association study , candidate gene , pathogenesis , gene , bioinformatics , immunology , medicine , dna methylation , genotype , pathology , gene expression
Abstract Systemic sclerosis ( SS c) is an immune‐mediated connective tissue disease of which the aetiology is still unclear. Previous genetic studies including candidate‐gene studies and genomewide association studies have identified a number of genetic variations that confer risk to SS c. However, these variants, such as single nucleotide polymorphisms, cannot completely explain the SS c susceptibility and the diversity in the clinical symptoms of SS c patients. The contribution of epigenetic mechanisms as a link between genetics and environmental triggers represents promising field in understanding the pathogenesis of SS c. The aim of this review was to present the current knowledge on epigenetic mechanisms and highlight novel directions in diagnostic and therapeutical approaches.