Premium
The Lymphocytes Stimulation Induced DNA Release, a Phenomenon Similar to NET osis
Author(s) -
Rocha Arrieta Y. C.,
Rojas M.,
Vasquez G.,
Lopez J.
Publication year - 2017
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12592
Subject(s) - stimulation , dna , microbiology and biotechnology , chemistry , medicine , biology , immunology , genetics
The release of DNA into the extracellular milieu by neutrophil during a process called NET osis has been postulated as an additional source of autoantigens; a process believed to be important in the pathogenesis of some autoimmune disease, such as systemic lupus erythematosus ( SLE ). However, it is not established if the B and T cells undergo the release of DNA to the extracellular milleu, in response to different stimuli. In this study, it was observed that the treatment of B and T cells with PMA , ionomycin and the serum from patients with SLE induced the extracellular DNA presence in B and T cells. These findings suggest that the phenomenon were similar to those observed in neutrophil's Etosis; B and T cells also released their DNA into the extracellular milieu. The findings express that serum from patients with SLE and SLEDAI ≤ 8 triggers the release of extracellular DNA in neutrophils, B and T cells, that suggested the presence of soluble factors in the serum that favoured this phenomenon.