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Mucosal‐associated Invariant Cells are Deficient in Systemic Sclerosis
Author(s) -
Mekinian A.,
Mahevas T.,
Mohty M.,
Jachiet V.,
Rivière S.,
Fain O.,
Gaugler B.
Publication year - 2017
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12585
Subject(s) - scleroderma (fungus) , medicine , immune system , multiple sclerosis , immunology , fibrosis , autoimmune disease , interstitial lung disease , disease , systemic disease , systemic scleroderma , lung , pathology , immunopathology , antibody , inoculation
Systemic sclerosis ( SS c) is an autoimmune disease, characterized by fibrosis of the skin and other organs, vascular impairment and deficient immune responses. Mucosal‐associated invariant T cells ( MAIT ) have been involved in various inflammatory and autoimmune diseases. The aims of this study were to determine the frequencies of MAIT cells in the blood of patients with systemic sclerosis ( SS c) and to compare their distribution in different types of SS c. Blood samples from patients with SS c and healthy controls were examined by flow cytometer to analyse the frequencies of MAIT and γδ T cells. We demonstrate that in SS c the frequencies and absolute numbers of MAIT and γδ T cells are significantly reduced in comparison with healthy controls. MAIT and γδ T cells did not correlate with C‐reactive protein, BNP , pulmonary involvement or median skin fibrosis scale, steroid amount or disease duration. In addition, MAIT and γδ T cells decrease did not stratify with gender, interstitial lung disease or active digital ulcers. Functional studies are necessary to determine the signification of MAIT cells decrease in systemic sclerosis.