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Approach to the Management of Autoimmunity in Primary Immunodeficiency
Author(s) -
Azizi G.,
Ziaee V.,
Tavakol M.,
Alinia T.,
Yazdai R.,
Mohammadi H.,
Abolhassani H.,
Aghamohammadi A.
Publication year - 2017
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12506
Subject(s) - autoimmunity , primary immunodeficiency , immunodeficiency , immunology , immune system , medicine , inflammation , human immunodeficiency virus (hiv) , immunopathology
Primary immunodeficiency diseases ( PID s) consist of a genetically heterogeneous group of immune disorders that affect distinct elements of the immune system. PID patients are more prone to infections and non‐infectious complications, particularly autoimmunity. The concomitance of immunodeficiency and autoimmunity appears to be paradoxical and leads to difficulty in the management of autoimmune complications in PID patients. Therefore, management of autoimmunity in patients with PID requires special considerations because dysregulations and dysfunctions of the immune system along with persistent inflammation impair the process of diagnosis and treatment.