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New Aspects of the Biology of Neutrophil Extracellular Traps
Author(s) -
Dąbrowska D.,
Jabłońska E.,
Garley M.,
RatajczakWrona W.,
Iwaniuk A.
Publication year - 2016
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12494
Subject(s) - neutrophil extracellular traps , extracellular , signalling pathways , intracellular , biology , microbiology and biotechnology , programmed cell death , immune system , signal transduction , signalling , immunology , innate immune system , inflammation , genetics , apoptosis
The formation and release of neutrophil extracellular traps ( NET s) discovered in 2004 by Volker Brinkmann and Arturo Zychlinsky cast a new light on the role of neutrophils in the non‐specific immune response of the body. This discovery has resulted in the rapid development of neutrophil studies in different bacterial and autoimmune diseases as well as neoplasms. Research is also being performed on the role of different signalling pathways engaged in the induction of NET osis, a unique form of a programmed cell death leading to the creation of NET s. The literature provides information on the structure and composition of neutrophil extracellular traps. This review presents the latest data on NET formation and the role of their key components, as well as describing the intracellular signalling pathways leading to the generation of NET s that have been discovered.