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Myeloid‐Derived Suppressor Cells in Cancers and Inflammatory Diseases: Angel or Demon?
Author(s) -
Su Z.,
Ni P.,
Zhou C.,
Wang J.
Publication year - 2016
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12473
Subject(s) - myeloid derived suppressor cell , immunosuppression , suppressor , immunology , immune system , population , cancer , cancer research , biology , myeloid , innate immune system , inflammation , medicine , genetics , environmental health
Myeloid‐derived suppressor cell ( MDSC ) is an important heterogeneous cell population that regulates innate and adaptive immune. The immunosuppressive potentiality is widely known. However, more and more data indicated that the heterogeneous cell population had immunostimulatory activities rather than immunosuppression in some microenvironments. Chronic inflammatory conditions contribute to accumulation of MDSC s. These pathologically activated cells played critical roles in cancer and inflammatory diseases. In this review, we mainly discuss the immunoregulation potentiality of MDSC s in cancer and inflammatory diseases.