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Contemplating Bretscher's View that the Tritope Model is ‘Implausible’
Author(s) -
Cohn M.
Publication year - 2016
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12458
Subject(s) - epistemology , philosophy
There is, at present, only two models of the TCR structure–function relationship. These are referred to here as the Standard (Centric) model and the Tritope model. While I have argued that the Standard model is untenable and proposed the Tritope to replace it, Bretscher has argued that the Tritope model is ‘implausible’ and throws his support for the Standard model. This essay analyses the implausibility argument concluding that it is unfounded.