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Effects of Anti‐ CD 45 RB Monoclonal Antibody for T Lymphocyte Subsets in Mice Heart Transplantation Model
Author(s) -
Deng C.Y.,
Wang X.F.,
Qi H.,
Li F.R.
Publication year - 2016
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12446
Subject(s) - immune system , monoclonal antibody , immunology , biology , immunosuppression , t cell , t lymphocyte , lymphocyte , immune tolerance , microbiology and biotechnology , antibody , transplantation , cd8 , medicine
Abstract Anti‐ CD 45 RB monoclonal antibody (anti‐ CD 45 RB mAb), as a new immune tolerance inducer, may inhibit T cell proliferation and induce immune tolerance through competitive combination with CD 45 RB on the T cell surface, which blocks the conduction of activation signals. However, how anti‐ CD 45 RB mAb plays its role on T lymphocyte subsets during immunosuppression remains unclear. In this work, we investigate the effects of anti‐ CD 45 RB mAb on CD 3 + T lymphocyte both in vitro and in allogeneic heart transplant model in vivo . Interestingly, anti‐ CD 45 RB mAb could inhibit the proliferation of T cells, promote the transformation of T lymphocyte to Treg and Th2 cells, suppress the transformation to Th17 and Th1 cells, increase the number of Ts cells, decrease the number of Tm cells and thus play a role in immune inhibition and induction of immune tolerance.