Effects of Anti‐ CD 45 RB Monoclonal Antibody for T Lymphocyte Subsets in Mice Heart Transplantation Model

Anti‐ CD 45 RB monoclonal antibody (anti‐ CD 45 RB mAb), as a new immune tolerance inducer, may inhibit T cell proliferation and induce immune tolerance through competitive combination with CD 45 RB on the T cell surface, which blocks the conduction of activation signals. However, how anti‐ CD 45 RB mAb plays its role on T lymphocyte subsets during immunosuppression remains unclear. In this work, we investigate the effects of anti‐ CD 45 RB mAb on CD 3 + T lymphocyte both in vitro and in allogeneic heart transplant model in vivo . Interestingly, anti‐ CD 45 RB mAb could inhibit the proliferation of T cells, promote the transformation of T lymphocyte to Treg and Th2 cells, suppress the transformation to Th17 and Th1 cells, increase the number of Ts cells, decrease the number of Tm cells and thus play a role in immune inhibition and induction of immune tolerance.