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The Role of Different Monocyte Subsets in the Pathogenesis of Atherosclerosis and Acute Coronary Syndromes
Author(s) -
Idzkowska E.,
Eljaszewicz A.,
Miklasz P.,
Musial W. J.,
Tycinska A. M.,
Moniuszko M.
Publication year - 2015
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12314
Subject(s) - cd16 , cd14 , monocyte , pathogenesis , immunology , medicine , inflammation , myocardial infarction , coronary atherosclerosis , coronary artery disease , antigen , immune system , cd3 , cd8
The inflammation underlying both atherosclerosis and acute coronary syndromes is strongly related to monocyte‐related actions. However, different monocyte subsets can play differential roles in the formation and destabilization of atherosclerotic plaque as well as healing of damaged myocardial tissue. Monocytes are currently being divided into three functionally distinct subsets with different levels of CD 14 (cluster of differentiation 14) and CD 16 expression. Thus, there are classical CD 14++ CD 16‐, intermediate CD 14++ CD 16+ and non‐classical CD 14+ CD 16++ monocytes. Here, we summarize the current knowledge on complex activities of different monocyte subsets in atherosclerosis and acute coronary syndromes. Moreover, we discuss which monocyte subsets can serve either as predictive biomarkers of cardiovascular risk or as potential targets used in atherosclerosis and its complications.