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Spin90 Deficiency Increases CXCL 13‐Mediated B Cell Migration
Author(s) -
Park S.H.,
Kim H.R.,
Jun C.D.,
Song W. K.,
Park S.G.
Publication year - 2014
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12203
Subject(s) - cxcl13 , microbiology and biotechnology , biology , business , genetics , chemokine , receptor , chemokine receptor
SPIN 90 regulates actin dynamics, which is important for cell migration control. CXCL 13‐mediated B cell migration is essential for B cell immune responses. In this study, we investigated the role of SPIN 90 in CXCL 13‐mediated B cell migration using Spin90 gene‐deficient mice. Our chemokinesis analysis and transwell cell migration assay showed that SPIN 90 is involved in CXCL 13‐mediated B cell migration. Moreover, the level of CXCR 5, which is CXCL 13 receptor, was increased in SPIN 90‐deficient B cells compared with wild‐type B cells. Overall, our data suggest that SPIN 90 plays an important role in B cell immune responses through the regulation of CXCL 13‐mediated B cell migration.