Spin90 Deficiency Increases CXCL 13‐Mediated B Cell Migration

SPIN 90 regulates actin dynamics, which is important for cell migration control. CXCL 13‐mediated B cell migration is essential for B cell immune responses. In this study, we investigated the role of SPIN 90 in CXCL 13‐mediated B cell migration using Spin90 gene‐deficient mice. Our chemokinesis analysis and transwell cell migration assay showed that SPIN 90 is involved in CXCL 13‐mediated B cell migration. Moreover, the level of CXCR 5, which is CXCL 13 receptor, was increased in SPIN 90‐deficient B cells compared with wild‐type B cells. Overall, our data suggest that SPIN 90 plays an important role in B cell immune responses through the regulation of CXCL 13‐mediated B cell migration.