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JAK/STAT Pathway in Drosophila Immunity
Author(s) -
Myllymäki H.,
Rämet M.
Publication year - 2014
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12170
Subject(s) - stat , janus kinase , jak stat signaling pathway , stat protein , biology , microbiology and biotechnology , transcription factor , signal transduction , stat4 , signalling , hedgehog signaling pathway , stat3 , effector , immunity , kinase , immune system , genetics , gene , tyrosine kinase
The Janus kinase/signal transducer and activator of transcription ( JAK / STAT ) signalling pathway controls multiple biological processes in metazoan development and tissue homoeostasis. This creates a need for tight regulatory mechanisms to ensure proper responses. The core components of the pathway, as well as many of the regulatory molecules, are conserved in evolution and thus share similarities in organisms such as humans and fruit flies. Therefore, the fruit fly provides an amenable model system for elucidating the in vivo roles of the JAK / STAT pathway and its regulators, which are challenging to demonstrate in mammalian systems. This review will focus on describing recent advances in understanding the importance of JAK / STAT signalling in Drosophila immunity.