Premium
Polymorphisms in the Interleukin‐1 Gene Locus and Chronic Periodontitis in Patients with Atherosclerotic and Aortic Aneurysmal Vascular Diseases
Author(s) -
Armingohar Z.,
Jørgensen J. J.,
Kristoffersen A. K.,
Schenck K.,
Dembic Z.
Publication year - 2014
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12166
Subject(s) - locus (genetics) , medicine , gene , periodontitis , immunology , biology , genetics
Chronic periodontitis ( CP ) and atherosclerotic and aortic aneurysmal vascular diseases ( VD ) are inflammatory conditions that share a number of predisposing factors. They have a complex genetic heritability and may share genetic risk factors, but a well‐defined relationship is still not determined. In addition, distinct genetic patterns of predisposition have been associated with these diseases. Here, we investigated the association of polymorphisms in the IL ‐1 gene locus with CP in a case–case study analysing VD patients with or without CP . Seventy‐four patients with VD of whom 36 had CP were genotyped for single nucleotide polymorphisms in the IL 1A ‐889 (rs1800587), IL 1B +3954 (rs1143634) and IL 1B at −511 (rs16944) genes and for VNTR polymorphisms in the IL 1 RN gene. A significantly higher frequency (17%) for allele 1 (four repeats) of the IL 1 RN VNTR gene was found among the VD patients with CP compared to those without CP . In addition, the frequency of the IL 1 RN VNTR genotypes 1/1 (4/4 repeats) and 2/2 (2/2 repeats) were significantly higher and lower, respectively, in VD patients with CP . These findings suggest an association of genetic polymorphisms in the IL 1‐gene locus with risk for CP in patients with VD . The carriage of the risk genotypes, the development and the subsequent influence of CP on systemic health may constitute an additional burden in the pathogenesis of VD . This emphasizes the importance of effective periodontal treatment in patients with VD .