Premium
Quinoline‐3‐Carboxamides Modulate Primary T Cell‐Dependent B Cell Responses but do not Inhibit Functional Immunity
Author(s) -
Källberg E.,
Ivars F.,
Leanderson T.
Publication year - 2014
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12152
Subject(s) - quinoline , primary (astronomy) , immunity , cell , cell mediated immunity , t cell , chemistry , biology , immunology , pharmacology , immune system , biochemistry , organic chemistry , physics , astronomy
Abstract The effect of a quinoline‐3‐carboxamide on the T cell‐dependent B cell response was investigated in C 57 BL /6 mice after NP ‐ CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline‐3‐carboxamide. This inhibition was paralleled by reduced numbers of germinal centre ( GC ) B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of GC s formed and their size were reduced by quinoline‐3‐carboxamide treatment. In contrast to the observation in the primary immune response, there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline‐3‐carboxamides can modulate immune function in autoimmune diseases without being immunosuppressive.