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Serum Vitamin D Levels and VDR Polymorphisms ( B sm I and F ok I ) in Patients and their Household Contacts Susceptible to T uberculosis
Author(s) -
Joshi L.,
Ponnana M.,
Penmetsa S. R.,
Nallari P.,
Valluri V.,
Gaddam S.
Publication year - 2014
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12127
Subject(s) - calcitriol receptor , vitamin d and neurology , immune system , medicine , vitamin , immunology , vitamin d deficiency , genotype , tuberculosis , endocrinology , chemistry , biochemistry , gene , pathology
Vitamin D , an immunomodulator of macrophage function, can activate human antimycobacterial activity. Vitamin D deficiency ( VDD ) is associated with an impaired mycobacterial immunity and susceptibility to tuberculosis. It has been found that vitamin D and its receptor may be essential for immune function. In this study, we examined the serum 25( OH ) vitamin D levels and its receptor ( VDR ) polymorphisms with susceptibility to tuberculosis in patients, household contacts and healthy controls. Serum 25( OH ) vitamin D levels were measured in 75 cases (25 patients, 25 household contacts and 25 healthy controls), and polymorphisms ( B sm I and F ok I ) were carried out in 335 cases (110 patients, 110 household contacts and 115 healthy controls). The proportion of serum 25( OH ) vitamin D deficiency and insufficiency was high in patients (44, 58%) and household contacts (40, 48%) compared to controls (48%). The BB and B b genotypes of B sm I were significantly associated in patients ( P < 0.014; OR : 0.509; CI : 0.265–0.876) ( P < 0.001; OR : 2.351; CI : 1.368–4.041) and household contacts ( P < 0.04; OR : 0.575; CI : 0.336–0.985); ( P < 0.002; OR : −2.267; CI : 1.32–3.895) when compared to healthy controls. The diplotype and MDR analysis showed the high‐risk genotypes of B sm I and F ok I polymorphisms. Vitamin D deficiency and its association with VDR gene polymorphisms may be useful to identify the high‐risk group individuals.