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Fc gamma Receptor II a‐ H 131 R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of M ali
Author(s) -
Maiga B.,
Dolo A.,
Touré O.,
Dara V.,
Tapily A.,
Campino S.,
Sepulveda N.,
Corran P.,
Rockett K.,
Clark T. G.,
Troye Blomberg M.,
Doumbo O. K.
Publication year - 2014
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12122
Subject(s) - malaria , allele , sympatric speciation , biology , parasite hosting , plasmodium falciparum , polymorphism (computer science) , allele frequency , immunology , microbiology and biotechnology , genetics , gene , world wide web , computer science
It has been previously shown that there are some interethnic differences in susceptibility to malaria between two sympatric ethnic groups of M ali, the F ulani and the D ogon. The lower susceptibility to P lasmodium falciparum malaria seen in the F ulani has not been fully explained by genetic polymorphisms previously known to be associated with malaria resistance, including haemoglobin S ( H b S ), haemoglobin C ( H b C ), alpha‐thalassaemia and glucose‐6‐phosphate dehydrogenase ( G 6 PD ) deficiency. Given the observed differences in the distribution of F cγ RII a allotypes among different ethnic groups and with malaria susceptibility that have been reported, we analysed the rs1801274‐ R 131 H polymorphism in the F cγ RII a gene in a study of D ogon and F ulani in M ali ( n = 939). We confirm that the F ulani have less parasite densities, less parasite prevalence, more spleen enlargement and higher levels of total I g G antibodies (anti‐ CSP , anti‐ AMA 1, anti‐ MSP 1 and anti‐ MSP 2) and more total I g E ( P < 0.05) compared with the D ogon ethnic group. Furthermore, the F ulani exhibit higher frequencies of the blood group O (56.5%) compared with the D ogon (43.5%) ( P < 0.001). With regard to the F cγ RII a polymorphism and allele frequency, the F ulani group have a higher frequency of the H allele ( F ulani 0.474, D ogon 0.341, P < 0.0001), which was associated with greater total I g E production ( P = 0.004). Our findings show that the F cγ RII a polymorphism might have an implication in the relative protection seen in the F ulani tribe, with confirmatory studies required in other malaria endemic settings.