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It has been previously shown that there are some interethnic differences in susceptibility to malaria between two sympatric ethnic groups of  M ali, the  F ulani and the  D ogon. The lower susceptibility to   P lasmodium falciparum  malaria seen in the  F ulani has not been fully explained by genetic polymorphisms previously known to be associated with malaria resistance, including haemoglobin  S  ( H b S ), haemoglobin  C  ( H b C ), alpha‐thalassaemia and glucose‐6‐phosphate dehydrogenase ( G 6 PD ) deficiency. Given the observed differences in the distribution of  F cγ RII a allotypes among different ethnic groups and with malaria susceptibility that have been reported, we analysed the rs1801274‐ R 131 H  polymorphism in the  F cγ RII a gene in a study of  D ogon and  F ulani in  M ali ( n  = 939). We confirm that the  F ulani have less parasite densities, less parasite prevalence, more spleen enlargement and higher levels of total  I g G  antibodies (anti‐ CSP , anti‐ AMA 1, anti‐ MSP 1 and anti‐ MSP 2) and more total  I g E  ( P  < 0.05) compared with the  D ogon ethnic group. Furthermore, the  F ulani exhibit higher frequencies of the blood group  O  (56.5%) compared with the  D ogon (43.5%) ( P  < 0.001). With regard to the  F cγ RII a polymorphism and allele frequency, the  F ulani group have a higher frequency of the  H  allele ( F ulani 0.474,  D ogon 0.341,  P  < 0.0001), which was associated with greater total  I g E  production ( P  = 0.004). Our findings show that the  F cγ RII a polymorphism might have an implication in the relative protection seen in the  F ulani tribe, with confirmatory studies required in other malaria endemic settings.

Fc gamma Receptor II a‐ H 131 R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of M ali