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The Role of Th17/Tc17 Peripheral Blood T cells in Psoriasis and Their Positive Therapeutic Response
Author(s) -
Eysteinsdóttir J. H.,
Sigurgeirsson B.,
Ólafsson J. H.,
Fridriksson Th.,
Agnarsson B. A.,
Davíðsson S.,
Valdimarsson H.,
Lúðvíksson B. R.
Publication year - 2013
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12114
Subject(s) - psoriasis , medicine , immune system , immunology , chemokine , pathogenesis , inflammation , tumor necrosis factor alpha
It is known that NB ‐ UVB therapy can suppress a broad range of immune cells, but the additional effect of bathing in geothermal seawater still remains unclear. To study the influence of treatment on the expression of circulating immune cells contributing to the pathogenesis of psoriasis, six patients with psoriasis were treated with bathing in geothermal seawater two times daily combined with NB ‐ UVB five times/week for 2 weeks and six patients were treated with NB ‐ UVB therapy three times/week for 8 weeks. Disease severity (Psoriasis Area and Severity Index, PASI ), chemokines, inflammatory cytokines, T cells and Toll‐like receptors in the blood and skin samples were evaluated on enrolment ( W 0) and at 1 ( W 1), 3 ( W 3) and 8 (W8) weeks. Compared with healthy controls, psoriasis patients with active disease had significantly higher proportion of peripheral CLA + T cells expressing CCR 10 and CD 103 and T cells with both Th1/Tc1 ( CD 4+/ CD 8+ IFN ‐γ+ or TNF ‐α+ cells) and Th17/Tc17 ( CD 4+ CD 45R0+ IL ‐23R+, CD 4+/ CD 8+ IL ‐17A+ or IL ‐22+ cells) phenotypes. Both treatments gave a significant clinical effect; however, bathing in geothermal seawater combined with NB ‐ UVB therapy was more effective than NB ‐ UVB therapy alone. This clinical improvement was reflected by a reduction in circulating CLA + peripheral blood T cells and by a decreased T h1/ T h17 and T c1/ T c17 inflammatory response. These findings suggest that the inflammatory response in psoriasis is predominantly driven by both CD 4+ and CD 8+ skin‐homing tissue retaining T cells of the T h17/ T c17 lineages.