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Suppression of Interferon‐Mediated Antiviral Immunity by Hepatitis B Virus: An Overview of Research Progress
Author(s) -
Guo P.
Publication year - 2013
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12086
Subject(s) - interferon , hepatitis b virus , clearance , virology , immunity , immunology , hepatitis b , medicine , virus , immune system , urology
Interferon ( IFN )‐α is an indispensable drug for hepatitis B treatment in clinical settings. However, hepatitis B virus ( HBV ) can attenuate IFN ‐mediated antiviral responses to avoid being inhibited or cleared. Much progress has been made in exploring how the IFN ‐induced anti‐ HBV effect is inhibited. This review examines and summarizes new advances regarding the molecular mechanism underlying the HBV ‐induced suppression of type I IFN ‐mediated antiviral immunity.