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Memory B Cells in Mouse Models
Author(s) -
Bergmann B.,
Grimsholm O.,
Thorarinsdottir K.,
Ren W.,
Jirholt P.,
Gjertsson I.,
Mårtensson I.L.
Publication year - 2013
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12073
Subject(s) - germinal center , memory b cell , naive b cell , b cell , antigen , b cell receptor , biology , antibody , b 1 cell , microbiology and biotechnology , memory cell , immunological memory , immunology , isotype , t cell , antigen presenting cell , immune system , monoclonal antibody , immunity , physics , transistor , quantum mechanics , voltage
One of the principles behind vaccination, as shown by E dward J enner in 1796, and host protection is immunological memory, and one of the cells central to this is the antigen‐experienced memory B cell that responds rapidly upon re‐exposure to the initiating antigen. Classically, memory B cells have been defined as progenies of germinal centre ( GC ) B cells expressing isotype‐switched and substantially mutated B cell receptors ( BCR s), that is, membrane‐bound antibodies. However, it has become apparent over the last decade that this is not the only pathway to B cell memory. Here, we will discuss memory B cells in mice, as defined by (1) cell surface markers; (2) multiple layers; (3) formation in a T cell–dependent and either GC ‐dependent or GC ‐independent manner; (4) formation in a T cell–independent fashion. Lastly, we will touch upon memory B cells in; (5) mouse models of autoimmune diseases.