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Tumour Regression Induced by Co‐administration of MIP ‐3α and C p G in an Experimental Model of Colon Carcinoma
Author(s) -
Arab S.,
Mojarrad M.,
Motamedi M.,
Mirzaei R.,
Modarressi M. H.,
Hadjati J.
Publication year - 2013
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12058
Subject(s) - colon carcinoma , cancer research , carcinoma , chemistry , medicine , colorectal cancer , cancer
CCL 20/macrophage inflammatory protein‐3α ( MIP ‐3α) represents one of the potent chemoattractive proteins for dendritic cells ( DC s). Herein, we investigated whether in vivo genetic modification of tumour cells aimed at intratumoural production of MIP ‐3α might lead to accumulation of DC s in tumour tissue. Mice injected with CT 26 , received recombinant adenovirus (Ad) vectors (Ad MIP ‐3α) expressing MIP ‐3α protein. This was complemented by injections of C p G . Interestingly, MIP ‐3α gene therapy combined with C p G injections resulted in specific cytotoxicity. This was associated with significant suppression of tumour growth rate. These findings demonstrate the potential of strategies that utilize in vivo overexpression of chemokines.