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Antioxidant Status and Oxidative Stress in Patients with Chronic ITP
Author(s) -
Jin C.Q.,
Dong H.X.,
Cheng P.P.,
Zhou J.W.,
Zheng B.Y.,
Liu F.
Publication year - 2013
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/sji.12048
Subject(s) - malondialdehyde , oxidative stress , glutathione , glutathione peroxidase , superoxide dismutase , antioxidant , chemistry , medicine , platelet , endocrinology , immunology , biochemistry , enzyme
The aim of this study was to establish the antioxidant status and oxidative stress in adult patients with chronic idiopathic thrombocytopenic purpura ( ITP ). Eighty‐four patients diagnosed with chronic ITP were studied. Fifty‐eight age‐matched healthy subjects were selected as controls. Serum nitrogen monoxide ( NO ), oxidized glutathione ( GSSG ), malondialdehyde ( MDA ), total antioxidant status ( TAS ), total oxidant status ( TOS ), superoxide dismutase( SOD ), hydrogen peroxide enzyme ( CAT ), glutathione peroxidase ( GSH ‐ P x), glutathione ( GSH ) were evaluated by enzyme‐linked immunosorbent assay ( ELISA ). It was found that serum SOD , CAT , GSH ‐Px, GSH , TAS levels were significantly lower in patients with chronic ITP than controls (all P < 0.05), while serum NO , GSSG , MDA , TOS values were significantly higher ( P < 0.05). The number of platelet showed a negative correlation with NO , GSSG , MDA , TOS , respectively,while platelet number showed a positive correlation with SOD , CAT , GSH ‐Px, GSH , TAS . These findings suggested that oxidants were increased and antioxidants were decreased in patients with chronic ITP , these may be prominent factors in destructing the platelet membrane. The scavenging of oxygen radical provides a theoretical basis for the treatment of ITP patients.