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Hemodialysis‐induced cardiovascular disease
Author(s) -
Ahmadmehrabi Shadi,
Tang W. H. Wilson
Publication year - 2018
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/sdi.12694
Subject(s) - medicine , hemodialysis , disease , kidney disease , end stage renal disease , anemia , context (archaeology) , uremia , intensive care medicine , cardiology , population , paleontology , environmental health , biology
Abstract More than half of all deaths among end stage renal disease ( ESRD ) patients are due to cardiovascular disease ( CVD ). Cardiovascular changes secondary to renal dysfunction, including fluid overload, uremic cardiomyopathy, secondary hyperparathyroidism, anemia, altered lipid metabolism, and accumulation of gut microbiota‐derived uremic toxins like trimethylamine N ‐oxidase, contribute to the high risk for CVD in the ESRD population. In addition, conventional hemodialysis ( HD ) itself poses myocardial stress and injury on the already compromised cardiovascular system in uremic patients. This review will provide an overview of cardiovascular changes in chronic kidney disease and ESRD , a description of reported mechanisms for HD ‐induced myocardial injury, comparison of HD with other treatment modalities in the context of CVD , and possible management strategies.