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Autonomic dysfunction as a mechanism of intradialytic blood pressure instability
Author(s) -
Shafi Tariq,
Mullangi Surekha,
Jaar Bernard G.,
Silber Harry
Publication year - 2017
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/sdi.12635
Subject(s) - medicine , blood pressure , mechanism (biology) , autonomic nervous system , dialysis , disease , intensive care medicine , sympathetic nervous system , cardiology , heart rate , philosophy , epistemology
The autonomic nervous system ( ANS ) is the principal endogenous defense mechanism that maintains blood pressure in the setting of hypotension. Disruption of the ANS impairs this ability and can contribute to blood pressure instability, including hypotension and hypertension. In this narrative review, we provide an overview of the ANS and the consequences of its dysfunction in patients with end‐stage kidney disease treated with dialysis. We also discuss possible mechanisms of this autonomic dysfunction that may need future investigation.