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Role of vascular calcification inhibitors in preventing vascular dysfunction and mortality in hemodialysis patients
Author(s) -
Gungor Ozkan,
Kocyigit Ismail,
Yilmaz Mahmut Ilker,
Sezer Siren
Publication year - 2017
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/sdi.12616
Subject(s) - medicine , calcification , pathogenesis , hemodialysis , cardiology , disease , vascular disease , population , kidney disease , intensive care medicine , environmental health
Cardiovascular events make up the primary cause of death in hemodialysis patients, and the risk for cardiovascular mortality is significantly increased by vascular calcification, a condition observed frequently in this patient population. The mechanisms underlying the pathogenesis of vascular calcification are complex, and many factors facilitate or hinder the development of calcification. In this review, we first summarize the main factors contributing to the pathogenesis of vascular calcification in patients with end‐stage renal disease. We then explore the role of calcification inhibitors in the calcification process, as well as their effect on vascular dysfunction and mortality in hemodialysis patients.