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We use Continuous Renal Replacement Therapy for Overdoses and Intoxications
Author(s) -
Cabrera Valerie Jorge,
Shirali Anushree C.
Publication year - 2016
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/sdi.12505
Subject(s) - medicine , renal replacement therapy , hemoperfusion , hemofiltration , intensive care medicine , hemodialysis , extracorporeal , dialysis , modalities , surgery , social science , sociology
Extracorporeal modalities for the removal of drugs and toxins are indicated for the treatment of overdoses and intoxications. Well‐established modalities include hemodialysis ( HD ), high‐flux HD (HfD), and charcoal hemoperfusion ( HP ). Recently, there have been increasing reports on the use of continuous renal replacement therapy ( CRRT ), such as continuous veno‐venous hemodialysis ( CVVHD ), continuous veno‐venous hemofiltration ( CVVH ) or CVVH combined with dialysis ( CVVHDF ). In the present article, we will discuss the various factors that determine the clearance of drugs and toxins and accordingly, we will propose that with few exceptions, CRRT does not have a role in the routine management of intoxications.