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Vitamin D‐Binding Protein in Health and Chronic Kidney Disease
Author(s) -
Denburg Michelle R.,
Bhan Ishir
Publication year - 2015
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/sdi.12422
Subject(s) - vitamin d binding protein , vitamin d and neurology , medicine , immune system , vitamin , kidney disease , albumin , binding protein , phenotype , endocrinology , disease , immunology , biochemistry , gene , biology
Vitamin D‐binding protein ( DBP ) is a multifunctional protein that has attracted increasing interest in recent years, largely because of its potential role in modulating the activity of vitamin D. Nearly all circulating vitamin D (~85–90%) circulates bound to DBP , with a smaller proportion bound to albumin, leaving <5% circulating freely. DBP may also play roles beyond vitamin D binding, with potential roles in the immune system and elsewhere. Numerous polymorphisms of DBP exist around the world, and recent studies have identified relevance of different DBP phenotypes in determining DBP concentration and vitamin D affinity. This review focuses on the known roles of DBP in health and kidney disease, and current views on the relevance of DBP polymorphisms.