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Clinical Evidence on Hemodiafiltration: A Systematic Review and a Meta‐analysis
Author(s) -
Mostovaya Ira M.,
Blankestijn Peter J.,
Bots Michiel L.,
Covic Adrian,
Davenport Andrew,
Grooteman Muriel P.C.,
Hegbrant Jörgen,
Locatelli Francesco,
Vanholder Raymond,
Nubé Menso J.
Publication year - 2014
Publication title -
seminars in dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 78
eISSN - 1525-139X
pISSN - 0894-0959
DOI - 10.1111/sdi.12200
Subject(s) - medicine , meta analysis , randomized controlled trial , hemodialysis , intensive care medicine , clinical trial , systematic review , medline , political science , law
In this review, a systematic literature search and meta‐analysis were performed to assess the effects of hemodiafiltration (HDF) on clinical outcome, as compared with hemodialysis (HD). Furthermore, the relation between the convection volume in HDF and clinical outcome was studied. The literature search identified six randomized controlled trials (RCTs). In a meta‐analysis of these RCTs, HDF treatment was related to a decreased risk of mortality (RR: 0.84; 95% CI 0.73–0.96) and cardiovascular death (RR: 0.73; 95% CI 0.57–0.92). Post hoc analyses of the three largest RCTs suggested an inverse relation between the magnitude of convection volume and mortality risk. The evidence presented in this analysis supports a wider acceptance of HDF.