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Influence of insulin on the healing of exposed dental pulp after pulp capping: An experimental study in a dog model
Author(s) -
AlAnesi Mokhtar A.,
AbuSeida Ashraf M.,
El Ashry Salma H.,
Mahran Abeer H.,
AbdElhamid Ehab S.
Publication year - 2020
Publication title -
special care in dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.328
H-Index - 41
eISSN - 1754-4505
pISSN - 0275-1879
DOI - 10.1111/scd.12545
Subject(s) - medicine , mineral trioxide aggregate , dentistry , pulp (tooth) , pulp capping , insulin , diabetes mellitus , endocrinology
Background This study investigates the influence of insulin on pulp tissue healing after pulp capping in diabetic dogs. Methods Diabetes mellitus was induced in four dogs, and their blood glucose levels were adjusted by insulin to normoglycemic level in two dogs (normoglycemic group) and to hyperglycemic level in two dogs (hyperglycemic group). Class V buccal cavities were performed in 15 teeth in each diabetic dog and two normal dogs (control group). The three groups (30 teeth each) were divided according to the capping materials into three subgroups (10 teeth each) including: subgroup A ‐ mineral trioxide aggregate (MTA), subgroup B ‐ bioaggregate (BA), and subgroup C ‐ calcium hydroxide (Ca(OH) 2 ). Each subgroup was divided into two subdivisions according to the evaluation period, subdivision 1: 1 month and subdivision 2: 2 months. Qualitative and quantitative evaluations of the inflammation and dentine bridge formation were assessed histologically. Results The hyperglycemic diabetic group exhibited significant higher inflammatory cell count and scores and lower dentine bridge thickness than those of the normoglycemic diabetic and control groups ( P < .05). There were no significant differences in these parameters between the normoglycemic diabetic and control groups ( P > .05). Conclusion Insulin has favourable effects on the pulp tissue healing after pulp capping in diabetic dogs.