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Evaluation of preventive laser photobiomodulation in patients with head and neck cancer undergoing radiochemotherapy: Laser in patients with head and neck cancer
Author(s) -
Dantas Juliana Borges de Lima,
Martins Gabriela Botelho,
Lima Hayana Ramos,
Carrera Manoela,
Reis Sílvia Regina de Almeida,
Medrado Alena Ribeiro Alves Peixoto
Publication year - 2020
Publication title -
special care in dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.328
H-Index - 41
eISSN - 1754-4505
pISSN - 0275-1879
DOI - 10.1111/scd.12486
Subject(s) - medicine , head and neck cancer , head and neck , cancer , surgery
Abstract Aims This study aimed to evaluate the effect of laser photobiomodulation in the prevention of oral mucositis (OM), salivary hypofunction and referred pain in patients with head and neck cancer. Methods and results This randomized clinical study divided patients into two groups: the laser group (LG, n = 30) and the control group (CG, n = 24). The LG (InGaAlP, 660 nm, 86.7 mW, 2 J/cm 2 ) participated in the preventive protocol, while the CG underwent a simulated procedure without light emission. The degree of OM, salivary flow, and referred pain were evaluated at five different periods of radiotherapy. Both groups showed a significant increase in the degree of OM ( P < .01). Regarding OM, salivary flow, and oral pain, there were no significant differences between the groups. Conclusions The laser photobiomodulation protocol used in this study was not effective in preventing radiochemotherapy‐induced OM, salivary hypofunction, and referred pain in patients with head and neck cancer. Notably, although the development of OM did not differ significantly according to the use of laser therapy, the severity of oral mucositis was reduced in patients who underwent laser therapy compared to that in patients who did not.