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Oral administration of nanomicelle curcumin in the prevention of radiotherapy‐induced mucositis in head and neck cancers
Author(s) -
Delavarian Zahra,
Pakfetrat Atessa,
Ghazi Ala,
Jaafari Mahmoud Reza,
Homaei Shandiz Fatemeh,
Dalirsani Zohreh,
Mohammadpour Amir Hooshang,
Rahimi Hamid Reza
Publication year - 2019
Publication title -
special care in dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.328
H-Index - 41
eISSN - 1754-4505
pISSN - 0275-1879
DOI - 10.1111/scd.12358
Subject(s) - mucositis , medicine , curcumin , head and neck cancer , radiation therapy , placebo , head and neck , side effect (computer science) , oral administration , oncology , cancer , clinical trial , surgery , pharmacology , pathology , alternative medicine , computer science , programming language
Oral mucositis (OM) is a complication of head and neck cancer (HNC) therapy with negative impact on the quality of life. Although definitive treatment has not yet been established, there is interest towards the use of natural compounds owing to their few side effects. Curcumin has a variety of biological and pharmacological properties including anticancer and anti‐inflammatory effects. Aim The aim of this study is to evaluate the effect of curcumin in the form of nanomicelle on OM in HNC patients receiving radiotherapy. Methods In this clinical trial, 32 HNC patients were allocated to case and control groups, and respectively received nanocurcumin or placebo during radiotherapy. Results We found a statistically significant difference in the severity of mucositis between the 2 groups at all visits. In contrast to the control‐group patients, who all developed OM in the 2nd week of radiotherapy, only 32% of the case group developed OM with no obvious oral or systemic side effects. Conclusion Our data show that nanomicelle curcumin is an effective agent in the prevention of OM or reducing its severity. Thus, the administration of nanocurcumin can be considered as a reasonable approach to hinder the development of OM in HNC patients requiring radiotherapy.