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Rare labial ulcer related to the use of all‐ trans retinoic acid in a patient with acute promyelocytic leukemia
Author(s) -
Buligon MP,
Mielke JC,
Chiesa J,
Ferrazzo KL
Publication year - 2018
Publication title -
special care in dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.328
H-Index - 41
eISSN - 1754-4505
pISSN - 0275-1879
DOI - 10.1111/scd.12293
Subject(s) - medicine , acute promyelocytic leukemia , leukocytosis , retinoic acid , myeloid leukemia , leukemia , gastroenterology , cancer , dermatology , biochemistry , chemistry , gene
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). All‐ trans retinoic acid (ATRA) is the first‐choice therapy for the treatment of this disease, but has been associated with side effects, the most serious of which is retinoic acid syndrome (RAS). RAS is characterized by unexplained fever, dyspnea, pulmonary infiltrate, leukocytosis and nephropathy. Genital ulcers have been described in some cases, but only two cases of oral ulcers related to this syndrome have been described in the literature. This paper describes the third case of oral ulceration related to ATRA in a 32‐year‐old white man with diagnosis of APL. Clinicians should know the side effects of ATRA and identify oral ulcers resulting from this therapy. The prompt identification of these ulcers enables the institution of appropriate treatment and can therefore contribute to continuation of the patient's cancer treatment.