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Brown tumor of the jaws as a manifestation of tertiary hyperparathyroidism: A literature review and case report
Author(s) -
dos Santos Bethina,
Koth Valesca Sander,
Figueiredo Maria Antonia,
Salum Fernanda Gonçalves,
Cherubini Karen
Publication year - 2018
Publication title -
special care in dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.328
H-Index - 41
eISSN - 1754-4505
pISSN - 0275-1879
DOI - 10.1111/scd.12284
Subject(s) - brown tumor , medicine , giant cell , radiography , differential diagnosis , mandible (arthropod mouthpart) , pelvis , hyperparathyroidism , parathyroid hormone , lesion , giant cell tumor of bone , central giant cell granuloma , tertiary hyperparathyroidism , osteitis fibrosa cystica , pathology , maxilla , primary hyperparathyroidism , bone resorption , radiology , anatomy , secondary hyperparathyroidism , surgery , calcium , botany , biology , genus
Brown tumor of the jaws is a manifestation of hyperparathyroidism consisting of osteolytic lesions that show proliferation of multinucleated giant cells in the maxilla and/or mandible. Differential diagnosis of these lesions from local central giant‐cell granuloma is mandatory for the correct treatment of the patient. Radiographic and histopathological exams of the jaw lesion are not sufficient to determine the diagnosis, which requires laboratory tests including serum levels of calcium, alkaline phosphatase, parathyroid hormone (PTH) and phosphate, and radiographic examination of other bones as well, such as hand‐wrist, pelvis, and femur. We present here a brief literature review focusing on the clinical and radiographic features, diagnostic criteria and treatment of brown tumor and also report a case of the disease affecting the jaw.