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Denosumab‐related osteonecrosis of the jaws: successful management with a conservative surgical approach
Author(s) -
Póvoa Raphaela Capella,
Marlierè Daniel Amaral Alves,
Silveira Henrique Martins,
Pires Fábio Ramoa
Publication year - 2016
Publication title -
special care in dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.328
H-Index - 41
eISSN - 1754-4505
pISSN - 0275-1879
DOI - 10.1111/scd.12168
Subject(s) - medicine , denosumab , conservative management , bone density conservation agents , general surgery , surgery , osteoporosis , bone density
Denosumab‐related osteonecrosis of the jaws (DRONJ) is a recently described entity that shares many common clinical and radiological features with bisphosphonate‐related osteonecrosis of the jaws (BRONJ). The aim of the present study is to report a case of DRONJ affecting the anterior mandible of a 58‐year‐old male treated with denosumab to prevent skeletal‐related events associated with prostate cancer. Conservative surgery in conjunction with antibiotic therapy and discontinuation of denosumab use were effective in managing the condition and the patient remains free of clinical and radiological changes after a 38 month follow‐up.