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Quantifying Cancer Risk from Radiation
Author(s) -
Keil Alexander P.,
Richardson David B.
Publication year - 2018
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/risa.12947
Subject(s) - ionizing radiation , causal inference , range (aeronautics) , radiation , population , cancer , estimation , inference , human health , radiation exposure , statistics , environmental health , econometrics , toxicology , medicine , computer science , mathematics , nuclear medicine , irradiation , biology , physics , engineering , artificial intelligence , systems engineering , quantum mechanics , nuclear physics , aerospace engineering
Complex statistical models fitted to data from studies of atomic bomb survivors are used to estimate the human health effects of ionizing radiation exposures. We describe and illustrate an approach to estimate population risks from ionizing radiation exposure that relaxes many assumptions about radiation‐related mortality. The approach draws on developments in methods for causal inference. The results offer a different way to quantify radiation's effects and show that conventional estimates of the population burden of excess cancer at high radiation doses are driven strongly by projecting outside the range of current data. Summary results obtained using the proposed approach are similar in magnitude to those obtained using conventional methods, although estimates of radiation‐related excess cancers differ for many age, sex, and dose groups. At low doses relevant to typical exposures, the strength of evidence in data is surprisingly weak. Statements regarding human health effects at low doses rely strongly on the use of modeling assumptions.