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ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma
Author(s) -
Wark Peter A.B.,
Pathinayake Prabuddha S.,
Kaiko Gerard,
Nichol Kristy,
Ali Ayesha,
Chen Ling,
Sutanto Erika N.,
Garratt Luke W.,
Sohal Sukhwinder S.,
Lu Wenying,
Eapen Mathew S.,
Oldmeadow Christopher,
Bartlett Nathan,
Reid Andrew,
Veerati Punnam,
Hsu Alan C.Y.,
Looi Kevin,
Iosifidis Thomas,
Stick Stephen M.,
Hansbro Philip M.,
Kicic Anthony
Publication year - 2021
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.14003
Subject(s) - asthma , medicine , copd , immunology , gene expression , proteases , gene , biology , biochemistry , enzyme
ACE2 is the primary receptor for SARS‐CoV‐2. We demonstrate that lower airway expression of ACE2 is increased in older adults and males. Lower ACE2 expression in epithelial cells also occurs in people with asthma and is associated with reduced furin and increased ADAM‐17 expression. This may partly explain the relative sparing of people with asthma from severe COVID‐19. See related Editorial