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Abstracts
Author(s) -
The calcium sensing receptor's ability to detect changes in extracellular calcium Ca,
to maintain Ca,
homeostasis is well characterized,
Recently the CaSR has emerged as a putative drug target in asthma since it is upregulated in …,
and its agonists,
polyamines induce bronchoconstriction via the CaSR,
Further,
CaSR negative allosteric modulators can reduce airway contraction,
airway inflammation,
and airway smooth muscle thickness and fibrosis in a mixed allergen treated mouse model of asthma,
Therefore,
we sought to examine the involvement of the CaSR in,
airway responsiveness to the polyamines,
spermine
Publication year - 2019
Publication title -
respirology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.13492
Subject(s) - medicine , dermatology
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