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Pneumonia as a cardiovascular disease
Author(s) -
Restrepo Marcos I.,
Reyes Luis F.
Publication year - 2018
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.13233
Subject(s) - medicine , pneumonia , intensive care medicine , disease , heart failure , epidemiology , inflammation , pathogen , systemic inflammation , cause of death , community acquired pneumonia , complication , myocardial infarction , cardiology , immunology
Community‐acquired pneumonia (CAP) is an important cause of death around the globe. Up to 30% of patients admitted to hospital for CAP develop cardiovascular complications (i.e. new/worsening heart failure, new/worsening arrhythmias, myocardial infarctions and/or strokes), acutely and up to 10 years thereafter. Cardiac complications result from complex interactions between preexisting conditions, relative ischaemia, upregulation of the sympathetic system, systemic inflammation and direct pathogen‐mediated damage to the cardiovascular system. The exact mechanisms underlying the direct host–pathogen interactions are of great interest to identify potential therapeutic and preventative targets for CAP. In this review, we summarize the epidemiological data, risk factors and the pathogen‐driven cardiovascular damage affecting patients with CAP.