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Old age and underlying interstitial abnormalities are risk factors for development of ARDS after pleurodesis using limited amount of large particle size talc
Author(s) -
Shinno Yuki,
Kage Hidenori,
Chino Haruka,
Inaba Atsushi,
Arakawa Sayaka,
Noguchi Satoshi,
Amano Yosuke,
Yamauchi Yasuhiro,
Tanaka Goh,
Nagase Takahide
Publication year - 2018
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.13192
Subject(s) - ards , medicine , pleurodesis , pneumothorax , talc , surgery , malignant pleural effusion , acute respiratory distress , pleural effusion , radiology , lung , materials science , composite material
Background and objective Talc pleurodesis is commonly performed to manage refractory pleural effusion or pneumothorax. It is considered as a safe procedure as long as a limited amount of large particle size talc is used. However, acute respiratory distress syndrome (ARDS) is a rare but serious complication after talc pleurodesis. We sought to determine the risk factors for the development of ARDS after pleurodesis using a limited amount of large particle size talc. Methods We retrospectively reviewed patients who underwent pleurodesis with talc or OK‐432 at the University of Tokyo Hospital. Results Twenty‐seven and 35 patients underwent chemical pleurodesis using large particle size talc (4 g or less) or OK‐432, respectively. Four of 27 (15%) patients developed ARDS after talc pleurodesis. Patients who developed ARDS were significantly older than those who did not (median 80 vs 66 years, P = 0.02) and had a higher prevalence of underlying interstitial abnormalities on chest computed tomography (CT; 2/4 vs 1/23, P < 0.05). No patient developed ARDS after pleurodesis with OK‐432. This is the first case series of ARDS after pleurodesis using a limited amount of large particle size talc. Conclusion Older age and underlying interstitial abnormalities on chest CT seem to be risk factors for developing ARDS after talc pleurodesis.