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Modified GAP index for prediction of acute exacerbation of idiopathic pulmonary fibrosis in non‐small cell lung cancer
Author(s) -
Kobayashi Haruki,
Omori Shota,
Nakashima Kazuhisa,
Wakuda Kazushige,
Ono Akira,
Kenmotsu Hirotsugu,
Naito Tateaki,
Murakami Haruyasu,
Endo Masahiro,
Takahashi Toshiaki
Publication year - 2017
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.13075
Subject(s) - medicine , idiopathic pulmonary fibrosis , exacerbation , lung cancer , stage (stratigraphy) , incidence (geometry) , gastroenterology , survival rate , oncology , lung , paleontology , physics , optics , biology
Background and objective Predicting the incidence rate of acute exacerbation ( AE ) of idiopathic pulmonary fibrosis ( IPF ) and its prognosis in patients with non‐small cell lung cancer ( NSCLC ) and IPF is difficult. The aim was to study the incidence of IPF‐AE during the clinical course of the disease and its prognosis in patients with both NSCLC and IPF . Methods In this retrospective study, we compared the incidence rate of AE during the clinical course of the disease as well as the 1‐year survival rate and overall survival ( OS ) of patients with NSCLC and IPF using a modified gender, age and physiology ( mGAP ) staging system based on gender, age and percent predicted forced vital capacity. Results Of 43 patients with NSCLC and IPF included in the final analysis, 17 patients (40%; 95% CI : 26–54%) experienced AE during the clinical course of the disease. One‐year survival and median OS were 41.9% (95% CI: 28–57%) and 9.4 months, respectively. Further analysis showed that the incidence of IPF‐AE gradually increased and that the 1‐year survival rate and median OS gradually decreased with increasing mGAP index score and stage. Conclusion Our study suggested that mGAP index score and cancer stage may predict IPF‐AE and its prognosis in patients with NSCLC and IPF .