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Determinants of annual change in physical activity in COPD
Author(s) -
Clarenbach Christian F.,
Sievi Noriane A.,
Haile Sarah R.,
Brack Thomas,
Brutsche Martin H.,
Frey Martin,
Irani Sarosh,
Leuppi Jörg D.,
Thurnheer Robert,
Kohler Malcolm
Publication year - 2017
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.13035
Subject(s) - medicine , copd , context (archaeology) , cohort , dynamic hyperinflation , obstructive lung disease , lung function , pulmonary function testing , physical therapy , cardiology , lung volumes , lung , paleontology , biology
ABSTRACT Background and objective Daily physical activity ( PA ) is reduced in patients with COPD . Previous cross‐sectional analyses indicate various predictors for a low level of PA including airway obstruction, exacerbations and co‐morbidities. However, information from longitudinal studies evaluating PA in the context of disease progression, survival and co‐morbidities is scant. Methods In a heterogeneous cohort of COPD patients, we annually assessed the number of steps per day over 1 week and potential determinants including lung function, exacerbations and co‐morbidities. Univariable and multivariable mixed effect models were used to investigate associations between the change in steps per day (dependent variable) and possible predictors and their annual changes. Results A total of 177 COPD patients (46% GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage 1/2, 38% stage 3 and 16% stage 4) with a mean (min/max) follow‐up time of 2.7 (1/5) years were annually assessed. The number of steps per day decreased significantly over time ( P < 0.001) with a mean annual change of −508 steps. The decrease in activity was significantly associated with forced expiratory volume in 1 s ( FEV 1 ) % predicted ( P = 0.020) but not with annual changes in FEV 1 . Hyperinflation, exacerbations, co‐morbidities and their annual changes, and survival did not significantly affect change in PA . Conclusion COPD patients have a substantial decrease of PA over time. This decrease seems to be determined by the degree of airflow limitation. However, patients with a greater annual decline in lung function did not show a greater decrease in PA . The rate of decline in PA did not differ between survivors and non‐survivors in this cohort.