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Health‐related quality of life in idiopathic pulmonary fibrosis: Data from the A ustralian IPF R egistry
Author(s) -
Glaspole Ian N.,
Chapman Sally A.,
Cooper Wendy A.,
Ellis Samantha J.,
Goh Nicole S.,
Hopkins Peter M.,
Macansh Sacha,
Mahar Annabelle,
Moodley Yuben P.,
Paul Eldho,
Reynolds Paul N.,
Walters E.Haydn.,
Zappala Christopher J.,
Corte Tamera J.
Publication year - 2017
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12989
Subject(s) - medicine , idiopathic pulmonary fibrosis , bayesian multivariate linear regression , quality of life (healthcare) , proportional hazards model , depression (economics) , hospital anxiety and depression scale , multivariate analysis , population , vital capacity , multivariate statistics , univariate analysis , anxiety , physical therapy , linear regression , lung , lung function , diffusing capacity , environmental health , psychiatry , statistics , nursing , mathematics , machine learning , computer science , economics , macroeconomics
ABSTRACT Background and objective Studies analysing the effect of worsening pulmonary physiological impairment in idiopathic pulmonary fibrosis ( IPF ) with respect to quality of life have been limited to single centres or highly selected trial populations. The aim of this study was to determine the principal determinants of baseline and longitudinal health‐related quality of life ( HRQoL ) in a large unselected IPF population. Methods We used the Australian IPF Registry to examine the relationship between HRQoL , measured using the St George Respiratory Questionnaire ( SGRQ ), and demographic features, physiological features, co‐morbidities and symptoms. Linear regression analysis was performed to identify predictors of baseline HRQoL , linear mixed model analysis to determine the effect of time and forced vital capacity ( FVC ) on SGRQ and Cox proportional hazards regression to examine the relationship between HRQoL and all‐cause mortality. Results Baseline data from 516 patients were available (347 males; mean ( SD ) age: 71.3 ± 8.6 years). Univariate analysis showed significant associations between HRQoL and demographic, clinical and physiological features. However, multivariate analysis demonstrated independent associations only between SGRQ and dyspnoea (University of California San Diego Shortness of Breathlessness Questionnaire ( UCSD‐SOBQ ); R 2 = 0.71, P < 0.0001), cough severity (visual analogue scale; R 2 = 0.06, P < 0.0001) and depression (Hospital Anxiety and Depression Scale; R 2 = 0.04, P < 0.0001). Linear mixed‐effects modelling of combined baseline and longitudinal data confirmed these associations, as well as for FVC % predicted ( P = 0.005). Multivariate Cox proportionate‐proportional hazards regression analysis demonstrated no association between HRQoL and risk of mortality. Conclusion Cough, dyspnoea and depression are major symptomatic determinants of HRQoL in IPF . FVC decline is associated with worsening HRQoL .