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Oral administration of Clostridium butyricum CGMCC0313‐1 reduces ovalbumin‐induced allergic airway inflammation in mice
Author(s) -
Juan Zhang,
ZhaoLing Shi,
MingHua Zeng,
Chun Wei,
HaiXia Wu,
MengYun Liu,
JianQiong Huang,
YueJie Zheng,
Xin Sun
Publication year - 2017
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12985
Subject(s) - clostridium butyricum , medicine , immunology , ovalbumin , inflammation , degranulation , immune system , allergy , allergic inflammation , immunoglobulin e , mast cell , biology , bacteria , antibody , genetics , receptor
Background and objective Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of beneficial bacteria for allergic diseases recently. This study aimed at exploring whether Clostridium butyricum CGMCC0313 ‐1 ( C. butyricum ) can reduce ovalbumin ( OVA )‐induced allergic airway inflammation in a mouse model. Methods Mouse model of allergic airway inflammation induced via OVA was used in this study. C. butyricum was administered daily by the oral route during or after the sensitization. Airway function, pulmonary airway inflammation, mast cell degranulation, T helper (Th)‐specific and anti‐inflammatory cytokines, OVA ‐specific Ig, matrix metalloproteinase 9 ( MMP ‐9) and histopathological alterations were examined. Results C. butyricum significantly reduced lung resistance in the asthmatic mice. Pulmonary airway inflammation, mast cell degranulation, airway remodelling and the expression of OVA ‐specific IgE / G1 were suppressed by oral C . butyricum . It also reversed the imbalance of Th1/Th2 and increased the anti‐inflammatory cytokine IL ‐10. Conclusion C . butyricum reduces OVA ‐induced allergic airway inflammation in mice and might be an additional or supplementary therapy for allergic asthma.