Premium
COPD A ssessment T est for measurement of health status in patients with idiopathic pulmonary fibrosis: A cross‐sectional study
Author(s) -
Matsuda Toshiaki,
Taniguchi Hiroyuki,
Ando Masahiko,
Kondoh Yasuhiro,
Kimura Tomoki,
Kataoka Kensuke,
Sakamoto Koji,
Suzuki Atsushi,
Furukawa Taiki,
Hasegawa Yoshinori
Publication year - 2017
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12936
Subject(s) - medicine , intraclass correlation , idiopathic pulmonary fibrosis , spirometry , hospital anxiety and depression scale , cronbach's alpha , copd , construct validity , physical therapy , pulmonary function testing , anxiety , cross sectional study , gastroenterology , surgery , lung , pathology , psychometrics , asthma , patient satisfaction , psychiatry , clinical psychology
Background and objective The COPD Assessment Test ( CAT ) has been reported to have potential utility for measuring health status of idiopathic pulmonary fibrosis ( IPF ). Although the CAT has been developed for the assessment of COPD patients, it has not been fully evaluated exclusively in IPF . This study was designed to evaluate the validity of the CAT in IPF . Methods The clinical data for 106 consecutive subjects with newly diagnosed IPF who completed pulmonary function tests, partial pressure of oxygen in arterial blood ( PaO 2 ) at rest, 6‐min walk test ( 6MWT ), CAT , St George's Respiratory Questionnaire ( SGRQ ), modified Medical Research Council ( mMRC ) dyspnoea grade and Hospital Anxiety and Depression Scale ( HADS ), were analysed. We assessed the validity of the CAT in comparison with the SGRQ . Results The present subjects showed mild to moderate restrictive impairment on spirometry. Mean CAT score and total SGRQ were 12.8 ± 8.0 and 30.8 ± 17.7, respectively. The concurrent validity of the CAT score in comparison with the SGRQ total score was significant (r = 0.72, P < 0.001). Internal consistency (Cronbach's α = 0.869) and repeatability over 3 months (intraclass correlation coefficient = 0.742) of the CAT were also significant. Single regression analysis showed that the CAT had significant construct validity. In multiple regression analysis, mMRC , PaO 2 at rest, minimum SpO 2 during 6MWT and anxiety of HADS were independent predictors for the CAT . Conclusions The CAT is a valid health status measurement in IPF patients. Multiple regression analysis showed that the CAT was significantly correlated with dyspnoea severity, oxygenation impairment and anxiety.