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Increased neutrophil expression of pattern recognition receptors during COPD exacerbations
Author(s) -
Pouwels Simon D.,
van Geffen Wouter H.,
Jonker Marnix R.,
Kerstjens Huib A. M.,
Nawijn Martijn C.,
Heijink Irene H.
Publication year - 2017
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12912
Subject(s) - damp , pyrin domain , medicine , exacerbation , copd , receptor , decoy , immunology , tlr4 , rage (emotion) , glycation , inflammation , inflammasome , biology , physics , neuroscience , meteorology
Previously, we observed increased serum levels of damage‐associated molecular patterns ( DAMPs ) during COPD exacerbations. Here, gene expression of DAMP receptors was measured in peripheral blood neutrophils of COPD patients during stable disease and severe acute exacerbation. The expression of toll‐like receptor ( TLR )2, TLR4 and NLR family, pyrin domain‐containing 3 ( NLRP3 ) was significantly increased, while serum levels of the soluble form of the decoy receptor for advanced glycation end‐product ( sRAGE ) were decreased during exacerbation. Together, these data indicate that increased DAMP signalling contributes to activation of neutrophils during COPD exacerbations.