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Suspected pulmonary embolism in patients with pulmonary fibrosis: Discordance between ventilation/perfusion SPECT and CT pulmonary angiography
Author(s) -
Leuschner Gabriela,
Wenter Vera,
Milger Katrin,
Zimmermann Gregor S.,
Matthes Sandhya,
Meinel Felix G.,
Lehner Sebastian,
Neurohr Claus,
Behr Jürgen,
Kneidinger Nikolaus
Publication year - 2016
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12797
Subject(s) - medicine , pulmonary embolism , pulmonary angiography , radiology , perfusion , pulmonary fibrosis , pulmonary infarction , lung
Abstract Background and Objective Pulmonary embolism (PE) is a common differential diagnosis in patients with pulmonary fibrosis presenting with a clinical deterioration. Both ventilation/perfusion (V/Q)‐single photon emission computed tomography (SPECT) and computed tomographic pulmonary angiography (CTPA) are routinely used to detect PE. However, the value of V/Q‐SPECT and CTPA in this scenario has not been studied so far. We aimed to investigate the concordance of V/Q‐SPECT and CTPA in patients with pulmonary fibrosis and suspicion of pulmonary embolism. Methods A total of 22 consecutive patients with pulmonary fibrosis and clinical deterioration who underwent both V/Q‐SPECT and CTPA were included in the study and analyzed for the presence of pulmonary embolism. Results Nine of 22 patients (41%) had evidence for pulmonary embolism in V/Q‐SPECT, and two of these patients had matching evidence for pulmonary embolism in CTPA. In the other seven patients with positive findings in V/Q‐SPECT, no evidence of pulmonary embolism was found in CTPA. None of the 13 patients with a negative V/Q‐SPECT had evidence for pulmonary embolism in CTPA. Conclusion In patients with pulmonary fibrosis and suspected pulmonary embolism, pulmonary embolism is detected more frequently by V/Q‐SPECT than by CTPA. Thromboembolic disease is identified on CTPA only in a minority of patients with positive findings on V/Q‐SPECT. When making treatment decisions, clinicians should be aware of the high rate of discordant findings in V/Q‐SPECT and CTPA in this specific patient population.