Premium
Factors associated with radiologic progression of non‐cystic fibrosis bronchiectasis during long‐term follow‐up
Author(s) -
Park Jisoo,
Kim Sejoong,
Lee Yeon Joo,
Park Jong Sun,
Cho YoungJae,
Yoon Ho Il,
Lee Kyoungwon,
Lee ChoonTaek,
Lee Jae Ho
Publication year - 2016
Publication title -
respirology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.857
H-Index - 85
eISSN - 1440-1843
pISSN - 1323-7799
DOI - 10.1111/resp.12768
Subject(s) - medicine , bronchiectasis , cystic fibrosis , body mass index , pulmonary function testing , gastroenterology , lung
Abstract Background and objective Non‐cystic fibrosis (CF) bronchiectasis is a chronic airway inflammatory disease, exhibiting a diverse array of clinical courses. The purpose of this study was to determine the factors that predict radiologic progression of non‐CF bronchiectasis during a long‐term follow‐up. Methods We reviewed the electronic medical records that included pulmonary function test data from non‐CF bronchiectasis patients, who were older than 18 years of age with a follow‐up of computerized tomography for more than 5 years. The original Bhalla score was used to determine the radiologic severity of non‐CF bronchiectasis. Results A total of 155 patients (mean age, 59.6 years; male, 45.2%) were included for the final analysis. The mean follow up time was 7.11 ± 1.42 (5–10) years. The baseline Bhalla score was 9.52 ± 3.14 (4–19), and the change of Bhalla score was 0.55 ± 1.14 (−2 to 5). The Bhalla score was increased in 56 patients (36.1%) but not in 99 patients (63.9%). The Bhalla score change was significantly associated with the age at diagnosis ( p = 0.037), body mass index (BMI, p = 0.012), chronic infection of Pseudomonas aeruginosa ( p = 0.005) or isolation of nontuberculous mycobacterium ( p = 0.042) in respiratory specimens. In a multivariate analysis, BMI and isolation of P . aeruginosa were significantly related with the Bhalla score change. Conclusion The radiologic progression of non‐CF bronchiectasis was associated with lower BMI and isolation of P . aeruginosa in respiratory specimens.